Short CV/Education and training

    Professor at Department of Molecular Biology, Umeå University

  • 2001
    Post-doc, Cancer Research Center, Laval University, Quebec, Canada, Infection and tumorbiology

  • 2000
    Post-doc, Karolinska Institutet, Stockholm, Sweden, Infection and tumorbiology

  • 2000
    Post-doc, Karolinska Institutet, Stockholm, Sweden, Cellular microbiology

  • 1999
    Ph.D. Karolinska Institutet, Stockholm, Sweden, Cell and Tumor Biology

  • 1991
    B.S. Biology, University of Trieste, Trieste, Italy

Selected publications

  • Guerra L., Albihn A., Tronnersjö S., Yan Q., Guidi R., Stenerlöw B, Sterzenbach T., Josenhans C., Fox J.G., Schauer D.B., Thelestam M., Larsson LG, Henriksson M. and Frisan T. (2010). Myc is required for activation of the ATM-dependent checkpoints in response to DNA damage. PLoS One, 5:e8924.

  • Blazkova H., Krejcikova K., Moudry P., Frisan T., Hodny Z., and Bartek J. (2010). Bacterial Intoxication Evokes Cellular Senescence with Persistent DNA Damage and Cytokine Signaling. J Cell Mol Med 14, 357-367.

  • Guerra L., Guidi R., Slot I., Callegari S., Sompallae R., Carr H.S., Pickett C.L., Åström S., Eisele F., Wolf D., Frost J.A., Sjögren C., Masucci M.G., Frisan T. (2011) DNA damage triggers FEN1-dependent cytoskeleton remodeling and cell survival. J of Cell Science, 124, 2735-2742.

  • Frisan T., Coppotelli G., Dryselius R., Masucci M.G. (2012). Ubiquitin C-terminal hydrolase-L1 interacts with adhesion complexes and promotes cell migration, survival, and anchorage independent growth. FASEB J 26, 5060-70.

  • Guidi R., Guerra L., Levi L., Stenerlöw B., Fox J.G., Josenhans C., Masucci M.G., Frisan T. (2013). Chronic exposure to the cytolethal distending toxins of Gram-negative bacteria promotes genomic instability and altered DNA damage response. Cell. Micro. 15, 98-113.

  • Guidi R, Levi L, Rouf SF, Puiac S, Rhen M, Frisan T. (2013). Salmonella enterica delivers its genotoxin through outer membrane vesicles secreted from infected cells. Cell. Micro. 15, 2034-2050.

  • Fahrer J., Huelsenbeck J., Jaurich H., Dörsam B., Frisan T., Eich M., Roos W.P., Bernd Kainaa, Fritz G. (2014). Cytolethal distending toxin (CDT) is a radiomimetic agent and induces persistent levels of DNA double-strand breaks in human fibroblasts. DNA repair 18, 31-43.

  • Levi L., Toyooka T., Patarroyo M., Frisan T. (2015) Bacterial genotoxins promote inside-out integrin activation, formation of focal adhesion complexes and cell spreading. PLosOne PLoS One. 13, e0124119.

  • Del Bel Belluz L, Guidi R, Pateras IS, Levi L, Mihaljevic B, Rouf SF, Wrande M, Candela M, Turroni S, Nastasi C, Consolandi C, Peano C, Tebaldi T, Viero G, Gorgoulis VG, Krejsgaard T, Rhen M, Frisan T. (2016). The Typhoid Toxin Promotes Host Survival and the Establishment of a Persistent Asymptomatic Infection. PLoS Pathog. 12, e1005528.

    This paper was highlighted in Nature (2016), 532, 521: “Salmonella lives on thanks to toxin”, and has attracted scientific media attention (;

  • Seiwert N., Neitzel C., Stroh S., Frisan T., Audebert, M, Toulany M., Kaina B., and Fahrer J. (2017). AKT2 suppresses pro-survival autophagy triggered by DNA double-strand breaks in colorectal cancer cells: Cell Death and Disease, in press.

Membership in scientific bodies/juries

Commissions and experience

  • Coordinator KI doctoral program in Tumorbiology and Oncology, 2015 – 2017

  • Member of the European Workshop on Bacterial Protein Toxins (ETOX) steering committee, since 2007

  • Swedish Scientific coordinator for the SIDA-sponsored Network for Research and Training in Tropical Diseases in Central America (NeTropica), 2007 – 2011

  • Chairman of the Young Cancer Leaders at Karolinska Institutet, 2010 – 2011

Media coverage

Science and Society

  • 2010: Invited speaker at PhD Forum on “Communicating science” at the Institute of Cancer Research, Oslo University Hospital Norway. Title: "From experiments to papers: communicating science…a science by itself" (in English).

  • 2010 and 2011: Invited speaker for a popular lecture on the biology of cancer, Pordenone, Italy (in Italian).

  • 2012: Invited speaker at Tarmcancerdagen organized by the Mag och Tarmförbundet. Title: “Kan bakterier påverkar tarmcancer?” (in Swedish).

  • 2013: Invited speakers for a popular lecture on vaccines Pordenone, Italy (in Italian).


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