Short CV/Education and training

  • Angela Vincent qualified as a doctor in 1966 but after a year of residency decided to become a scientist and studied for a masters in Biochemistry at UCL. A series of lucky opportunities led her into the field of myasthenia gravis and autoantibodies. She spent over 40 years working on autoantibodies in neurological diseases, investigating their mechanisms with in vitro and in vivo techniques. She was an Honorary Consultant in Immunology and established/directed the international Clinical Neuroimmunology service in Oxford, allowing her and colleagues to collaborate with neurologists worldwide. She was Head of Department of Clinical Neurology (2005-2008), served on the MRC Neurosciences and Mental Health Board (2004-2008).

Selected publications

  • Vincent A, Newland C, Brueton L, Beeson D, Riemersma S, Huson S, Newsom-Davis J. 1995. Arthrogryposis multiplex congenita with maternal autoantibodies specific for a fetal antigen. Lancet 346, 24-25.

  • Jacobson L, Polizzi A, Morriss-Kay GM, Vincent A 1999 An animal model of antibody-mediated neurodevelopmental disease: arythrogryposis multiplex congenita caused by antibodies to fetal acetylcholine receptor. J Clin Invest 103; 1031-1038.

  • Dalton P, ...., Vincent A. Maternal neuronal antibodies associated with autism and a language disorder. Ann Neurol 2003;53:533-537.

  • Liguori R, Vincent A, Clover L, Avoni P, Plazzi G, Cortelli P, et al. Morvan's syndrome: peripheral and central nervous system and cardiac involvement with antibodies to voltage-gated potassium channels. Brain 2001;124:2417-2426.

  • Vincent A, Buckley C, Schott JM, Baker I, Dewar BK, Detert N, et al. Potassium channel antibody-associated encephalopathy: a potentially immunotherapy-responsive form of limbic encephalitis. Brain 2004;127:701-712.

  • Irani SR, Alexander S, Waters P, Kleopa KA, Pettingill P, Zuliani L, Peles E, Buckley C, Lang B, Vincent A. Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan's syndrome and acquired neuromyotonia. Brain 2010;133:2734-48.

  • Irani SR, Pettingill P, Kleopa KA, Schiza N, Waters P, Mazia C, et al. Morvan syndrome: Clinical and serological observations in 29 cases. Ann Neurol. 2012 Aug;72(2):241-55.

  • Chang, T., Alexopoulos, H., Pettingill, P., McMenamin, M., Deacon, R., Erdelyi, F., . . . Vincent, A. (2013). Immunization against GAD Induces Antibody Binding to GAD-Independent Antigens and Brainstem GABAergic Neuronal Loss. PLoS ONE, 8(9), e72921.

  • Carvajal-González A, .. Vincent A. Glycine receptor antibodies in PERM and related syndromes: characteristics, clinical features and outcomes. Brain 2014.

  • Wright S, Hashemi K, Stasiak L, Bartram J, Lang B, Vincent A, Upton AL. Epileptogenic effects of NMDAR antibodies in a passive transfer mouse model. Brain. 2015 1;138.3159-67

  • Wright S, Geerts AT, .........., Brouwer OF, Vincent A. Neuronal antibodies in pediatric epilepsy: Clinical features and long-term outcomes of a historical cohort not treated with immunotherapy. Epilepsia. 2016 May;57(5):823-31.

  • Coutinho E, Jacobson L, Pedersen MG, Benros ME, Nørgaard-Pedersen B, Mortensen PB, Harrison PJ, Vincent A.CASPR2 autoantibodies are raised during pregnancy in mothers of children with mental retardation and disorders of psychological development but not autism. J Neurol Neurosurg Psychiatry. 2017 Sep;88(9):718-721

  • Coutinho E, Menassa DA, Jacobson L, ....... Vincent A. Persistent microglial activation and synaptic loss with behavioral abnormalities in mouse offspring exposed to CASPR2-antibodies in utero. Acta Neuropathol. 2017 Oct;134(4):567-583.

  • Lennox BR, Palmer-Cooper EC, ......Vincent A, team PPs. Prevalence and clinical characteristics of serum neuronal cell surface antibodies in first-episode psychosis: a case-control study. The Lancet Psychiatry. 2017 Jan;4(1):42-8.

  • Dawes JM, Weir G, Middleton S,.......,Vincent A, Bennett DL. Immune or genetic mediated disruption of CASPR2 causes pain hypersensitivity due to enhanced primary afferent excitability Neuron 2018 Feb 8.

Selected projects

  • Current projects

  • Demonstration of pathogenic effects of autoantibodies in experimental models

  • Identification of novel antibody targets in diverse neurological diseases, eg narcolepsy

  • Hypothesis-driven study of the effects of maternal antibodies on fetal development in humans, using mouse maternal-to-fetal transfer model

Membership in scientific bodies/juries

  • Association of British Neurologists

  • International Society of Neuroimmunology

  • American Neurological Association

Media coverage

  • Nothing recent

Additional qualifications

  • MB BS, 1966

  • MSc Biochemistry, 1969

Soft Skills/Other activities and achievements

Additional interests

  • Human rights abuse

  • Member of the Medical Group of Amnesty UK; steering committee 1989-1998

  • Strong supporter of the Freedom from Torture foundation

Soft Skills

  • Mentoring younger men and women

Other activities and achievements/family

  • Four children (both daughters are clinician/scientists and have children)


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